Przeciwciała przeciwko dekarboksylazie glutaminianowej w surowicy

Przeciwciała przeciwko dekarboksylazie glutaminianowej w surowicy a zaburzenia neurologiczne: kiedy podejrzewać ich związek?

Goals: To discover completely different neurological manifestations with suspicion of being related to serum glutamate decarboxylase antibodies (GAD-Abs) in order to raised characterize anti-GAD neurological syndromes.

Strategies: Observational retrospective research together with all sufferers for whom GAD65-Abs titers in serum had been requested by the Neurology Division at La Paz College Hospital between 2015 and 2019. GAD-Abs had been measured by ELISA. Demographic knowledge, neurological signs, comorbidity with diabetes mellitus (DM) or with one other autoimmune illness, and GAD-Abs titers had been studied. Stiff-person syndrome, ataxia, encephalitis, and epilepsy had been thought-about typical anti-GAD neurological syndromes and had been in comparison with different atypical manifestations.

Outcomes: A complete of 173 sufferers (51.7% males, imply age 51.62) had been included. A progressive improve in requests of serum GAD-Abs has occurred over the past 5 years, particularly in sufferers with atypical neurological manifestations. GAD-Abs had been discovered within the serum of 22 sufferers (12.7%); of these, 15 (68.18%) suffered a typical anti-GAD syndrome. Presence of DM or one other organ-specific autoimmune illness was predictive of GAD-AB seropositivity (p < 0.001). 6.6% of requested sufferers with an atypical syndrome had GAD-Abs, however serum ranges had been considerably decrease than these present in sufferers with a typical syndrome (706.67 vs 1430.23 UI/mL; Mann-Whitney U, p = 0.034), and had been lastly recognized with one other neurological illness.

Conclusion: Serum GAD-Abs had been occasionally present in sufferers with medical phenotypes apart from these classically described as anti-GAD problems, and with very low titers. In typical anti-GAD syndromes, there’s a excessive comorbidity with DM and with different autoimmune illnesses, and excessive serum GAD-Abs ranges are often current.

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Semaphorin 6A (SEMA6A) Antibody
20-abx211651
  • EUR 411.00
  • EUR 300.00
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Semaphorin 6A (SEMA6A) Antibody
20-abx212108
  • EUR 411.00
  • EUR 300.00
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Semaphorin 6A (SEMA6A) Antibody
abx031679-400ul 400 ul
EUR 523
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Semaphorin 6A (SEMA6A) Antibody
abx031679-80l 80 µl
EUR 286
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Semaphorin 6A (SEMA6A) Antibody
abx031680-400ul 400 ul
EUR 523
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Semaphorin 6A (SEMA6A) Antibody
abx031680-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.
Semaphorin 6A (SEMA6A) Antibody
20-abx302320
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Mouse Semaphorin- 6A, Sema6a ELISA KIT
ELI-52928m 96 Tests
EUR 865
Human Semaphorin 6A (SEMA6A)ELISA Kit
201-12-1088 96 tests
EUR 440
  • This Semaphorin 6A ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.
Human Semaphorin- 6A, SEMA6A ELISA KIT
ELI-52440h 96 Tests
EUR 824
Human Semaphorin 6A(SEMA6A)ELISA Kit
GA-E1104HM-48T 48T
EUR 289
Human Semaphorin 6A(SEMA6A)ELISA Kit
GA-E1104HM-96T 96T
EUR 466
Human Semaphorin 6A(SEMA6A)ELISA Kit
QY-E00788 96T
EUR 361
Mouse anti-SAH 6a
MA00306-50 50µg
EUR 348
Description: Mouse monoclonal antibody to S-Adenosylhomocysteine Clone 844-2
Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN 50 µg
EUR 349
Anti-Rab 6A Antibody
A02911 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for Rab 6A Antibody (RAB6A) detection.tested for WB in Human, Mouse, Rat.
anti- Cytokeratin 6A antibody
FNab02215 100µg
EUR 548.75
  • Recommended dilution: WB: 1:5000-1:10000
  • IHC: 1:20-1:200
  • IF: 1:20-1:200
  • Immunogen: keratin 6A
  • Uniprot ID: P02538
  • Gene ID: 3853
  • Research Area: Cancer, Immunology, Developmental biology
Description: Antibody raised against Cytokeratin 6A
Anti-Cytokeratin 6A antibody
PAab02215 100 ug
EUR 386
Anti-Rab 6A antibody
STJ95302 200 µl
EUR 197
Description: Rabbit polyclonal to Rab 6A.
anti-Anti-Semaphorin 5A
YF-PA25252 50 ul
EUR 334
Description: Mouse polyclonal to Anti-Semaphorin 5A
anti-Semaphorin 3B
YF-PA15485 100 ug
EUR 403
Description: Rabbit polyclonal to Semaphorin 3B
anti-Semaphorin 3D
YF-PA22776 50 ug
EUR 363
Description: Mouse polyclonal to Semaphorin 3D
anti-Semaphorin 3D
YF-PA22777 100 ug
EUR 403
Description: Rabbit polyclonal to Semaphorin 3D
anti-Semaphorin 3B
YF-PA25020 50 ul
EUR 334
Description: Mouse polyclonal to Semaphorin 3B
anti-Semaphorin 7a
YF-PA25109 50 ul
EUR 334
Description: Mouse polyclonal to Semaphorin 7a
anti-Semaphorin 3A
YF-PA25559 50 ul
EUR 334
Description: Mouse polyclonal to Semaphorin 3A
anti- Cytokeratin 6A-specific antibody
FNab02216 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:200-1:1000
  • Immunogen: keratin 6A
  • Uniprot ID: P02538
  • Gene ID: 3853
  • Research Area: Cancer, Immunology, Developmental biology
Description: Antibody raised against Cytokeratin 6A-specific
Anti-Cytokeratin 6A-specific antibody
PAab02216 100 ug
EUR 386
Anti Mouse Semaphorin 3B Polyclonal Antibody
KR100
EUR 649
Description: The Anti Mouse Semaphorin 3B Polyclonal Antibody is available in Europe and for worldwide shipping via Gentaur.
Anti-Semaphorin 5A antibody
STJ70970 100 µg
EUR 359
Anti-Semaphorin 7a (3D3)
YF-MA16372 100 ug
EUR 363
Description: Mouse monoclonal to Semaphorin 7a
Anti-Semaphorin 7a (1G1)
YF-MA16373 100 ug
EUR 363
Description: Mouse monoclonal to Semaphorin 7a
Anti-Semaphorin 3A (5G9)
YF-MA17274 50 ug
EUR 363
Description: Mouse monoclonal to Semaphorin 3A
Anti-Semaphorin 4D (3B4)
YF-MA17342 100 ug
EUR 363
Description: Mouse monoclonal to Semaphorin 4D
Polyclonal Goat anti-GST α-form
GST-ANTI-1 50 uL
EUR 280
Polyclonal Goat anti-GST μ-form
GST-ANTI-2 50 uL
EUR 280
Polyclonal Goat anti-GST p-form
GST-ANTI-3 50 uL
EUR 280
CD6
6A-100T 100 test
EUR 349
Peptide 6A
H-6905.0005 5.0mg
EUR 297
Description: Sum Formula: C23H43N9O6; CAS# [73549-32-3]
Peptide 6A
H-6905.0025 25.0mg
EUR 1093
Description: Sum Formula: C23H43N9O6; CAS# [73549-32-3]
6a-Hydroxymaackiain
TB02758 5mg
EUR 847
6a-Senecioyloxychaparrin
TBZ0849 unit Ask for price
6a-Hydroxyeurycomalactone
TBZ1429 unit Ask for price
Anti-Semaphorin 3B/SEMA3B Antibody
A06559-1 100ug/vial
EUR 294
Anti-SEMA4A/Semaphorin 4A Antibody
A06779-1 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for SEMA4A Antibody (SEMA4A) detection.tested for WB in Human, Mouse, Rat, Monkey.
Anti-Semaphorin 3E/SEMA3E Antibody
A06937-2 100ug/vial
EUR 294
Anti-SEMA4C/Semaphorin 4C Antibody
A08069 100ul
EUR 397
Description: Rabbit Polyclonal SEMA4C/Semaphorin 4C Antibody. Validated in WB and tested in Human.
Anti-Semaphorin 3c/SEMA3C Antibody
A06444-1 100ug/vial
EUR 294
Anti-Semaphorin 3A/SEMA3A Antibody
A01761-1 100ug/vial
EUR 294
Anti-Semaphorin 3A/SEMA3A Antibody
PB9353 100ug/vial
EUR 294
Anti-Semaphorin 3E (internal) antibody
STJ71055 100 µg
EUR 359
Estriol 6a antibody
20-1630 100 ul
EUR 879
Description: Sheep polyclonal Estriol 6a antibody
Cytokeratin 6A Antibody
abx232215-100ug 100 ug
EUR 509
  • Shipped within 5-12 working days.
pFlag- CMV- 6a
PVT10705 2 ug
EUR 301
Mouse Keratin 6A (KRT6A) ELISA Kit
abx514580-96tests 96 tests
EUR 739
  • Shipped within 5-12 working days.
Semaphorin 5A
GT41026 100 ug
EUR 474
Semaphorin 7A
GT15076 100 ug
EUR 539
Semaphorin 3C
GT15077 100 ug
EUR 526
Semaphorin 6B
GT15165 100 ug
EUR 526
Semaphorin 5A
P41026 100 ug Blocking Peptide
EUR 239
Semaphorin 7A
MO15041 500 ug
EUR 513
Semaphorin 3B
RA25088 50 ul
EUR 474
Rab 6A Polyclonal Antibody
41378-100ul 100ul
EUR 252
Rab 6A Polyclonal Antibody
41378-50ul 50ul
EUR 187
Keratin 6A (KRT6A) Antibody
20-abx005878
  • EUR 411.00
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  • EUR 314.00
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Keratin 6A (KRT6A) Antibody
20-abx002875
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Keratin 6A (KRT6A) Antibody
20-abx214450
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Keratin 6A (KRT6A) Antibody
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Keratin 6A (KRT6A) Antibody
20-abx100825
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  • 100 ug
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Keratin 6A (KRT6A) Antibody
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  • 100 ug
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Keratin 6A (KRT6A) Antibody
20-abx100827
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  • 100 ug
  • 10 ug
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Keratin 6A (KRT6A) Antibody
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Keratin 6A (KRT6A) Antibody
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Keratin 6A (KRT6A) Antibody
abx146382-100ug 100 ug
EUR 391
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Keratin 6A (KRT6A) Antibody
20-abx159587
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Keratin 6A (KRT6A) Antibody
abx029191-400ul 400 ul
EUR 523
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Keratin 6A (KRT6A) Antibody
abx029191-80l 80 µl
EUR 286
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Keratin 6A (KRT6A) Antibody
20-abx322514
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Keratin 6A (KRT6A) Antibody
20-abx322515
  • EUR 439.00
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Keratin 6A (KRT6A) Antibody
20-abx304308
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
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  • EUR 300.00
  • 100 ug
  • 1 mg
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  • Shipped within 5-10 working days.
Cytokeratin 6A-specific Antibody
abx232216-100ug 100 ug
EUR 509
  • Shipped within 5-12 working days.
PDE 6A Polyclonal Antibody
ABP-PAB-31042 50 ug Ask for price
    • Product line: Miscellaneous
    • Brand:
Rab 6A Polyclonal Antibody
ABP55965-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from the Internal region of human Rab 6A at AA range: 90-170
  • Applications tips:
Description: A polyclonal antibody for detection of Rab 6A from Human, Mouse, Rat. This Rab 6A antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Rab 6A at AA range: 90-170
Rab 6A Polyclonal Antibody
ABP55965-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from the Internal region of human Rab 6A at AA range: 90-170
  • Applications tips:
Description: A polyclonal antibody for detection of Rab 6A from Human, Mouse, Rat. This Rab 6A antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Rab 6A at AA range: 90-170
Rab 6A Polyclonal Antibody
ABP55965-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from the Internal region of human Rab 6A at AA range: 90-170
  • Applications tips:
Description: A polyclonal antibody for detection of Rab 6A from Human, Mouse, Rat. This Rab 6A antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Rab 6A at AA range: 90-170
Rab 6A Polyclonal Antibody
ES6964-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Rab 6A from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA
Rab 6A Polyclonal Antibody
ES6964-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Rab 6A from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA
Recombinant Keratin 6A (KRT6A)
4-RPD234Hu01
  • EUR 440.48
  • EUR 221.00
  • EUR 1376.80
  • EUR 525.60
  • EUR 951.20
  • EUR 358.00
  • EUR 3292.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P02538
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 41.3kDa
  • Isoelectric Point: Inquire
Description: Recombinant Human Keratin 6A expressed in: E.coli
Recombinant Keratin 6A (KRT6A)
4-RPD234Ra01
  • EUR 476.32
  • EUR 230.00
  • EUR 1511.20
  • EUR 570.40
  • EUR 1040.80
  • EUR 382.00
  • EUR 3628.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q4FZU2
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 17.5kDa
  • Isoelectric Point: Inquire
Description: Recombinant Rat Keratin 6A expressed in: E.coli
Mouse Semaphorin 7A ELISA kit
E03S0083-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse Semaphorin 7A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse Semaphorin 7A ELISA kit
E03S0083-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse Semaphorin 7A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse Semaphorin 7A ELISA kit
E03S0083-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse Semaphorin 7A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse Semaphorin 3 ELISA kit
E03S0084-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Mouse Semaphorin 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse Semaphorin 3 ELISA kit
E03S0084-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse Semaphorin 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse Semaphorin 3 ELISA kit
E03S0084-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse Semaphorin 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse Semaphorin 4D ELISA kit
E03S0300-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A sandwich ELISA for quantitative measurement of Mouse Semaphorin 4D in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse Semaphorin 4D ELISA kit
E03S0300-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Mouse Semaphorin 4D in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse Semaphorin 4D ELISA kit
E03S0300-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A sandwich ELISA for quantitative measurement of Mouse Semaphorin 4D in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Podwójne dodatnie wyniki przeciwciał przeciwko β -glikoproteinie I domenie I i przeciw fosfatydyloserynie / protrombinie wzmacniają zarówno zakrzepicę, jak i dodatni wynik przeciwciał anty-ADAMTS13

Though just a few antiphospholipid syndrome (APS) happens with acquired thrombotic thrombocytopenic purpura (TTP), the connection between antiphospholipid antibodies (aPL) and anti-ADAMTS13 (anti-a disintegrin and metalloprotease with thrombospondin sort 1 motif, member 13) antibody stays unsure. We investigated the connection between high-risk thrombotic aPL and anti-ADAMTS13 antibody. 2 hundred and thirty-seven sufferers with optimistic lupus anticoagulant and/or anticardiolipin antibody had been included. Anti-β2GPI (anti-β2-glycoprotein I), anti-β2GPIdI (anti-β2-glycoprotein I area I), anti-PS/PT (anti-phosphatidylserine and prothrombin), ADAMTS13 exercise, and anti-ADAMTS13 antibody had been measured. Double positivity of anti-β2GPI and anti-PS/PT elevated thrombotic danger greater than three-fold and confirmed elevated positivity of anti-ADAMTS13 antibody compared with the double damaging group.

Double positivity of anti-β2GPIdI and anti-PS/PT offered each results much more. Within the linear regression evaluation, double positivity of anti-β2GPI and anti-PS/PT independently affected the anti-ADAMTS13 antibody stage (β = 1.982, P = 0.042). Our outcomes revealed that double positivity of anti-β2GPI or anti-β2GPIdI and anti-PS/PT elevated not solely thrombotic danger but in addition the positivity of anti-ADAMTS13 antibody, particularly indicating anti-β2GPIdI confirmed the next synergistic impact with anti-PS/PT. We propose a doable affiliation of anti-ADAMTS13 antibody with a excessive thrombotic danger of APS.

Double positivity of anti-β2GPI (anti-β2-glycoprotein I) and anti-PS/PT (anti-phosphatidylserine and prothrombin) antibodies enhanced not solely thrombotic danger but in addition positivity of anti-ADAMTS13 (anti-a disintegrin and metalloprotease with thrombospondin sort 1 motif, member 13) antibody. Moreover, double positivity of anti-β2GPIdI (anti-β2-glycoprotein I area I) mixed with anti-PS/PT much more elevated each thrombosis and positivity of anti-ADAMTS13 antibody. Double positivity of β2GPI and anti-PS/PT was discovered as an independently vital contributing issue to anti-ADAMTS13 antibody stage. We propose the affiliation between anti-ADAMTS13 antibody and the pathophysiology of antiphospholipid syndrome, which ought to be additional evaluated.

Strukturalny wpływ glikodendrymerów rekrutujących przeciwciała (ARG) na cytotoksyczność przeciwnowotworową

 

The recruitment of endogenous antibodies in opposition to most cancers cells has turn into a dependable antitumoral immunotherapeutic various over the past decade. The covalent attachment of antibody and tumor binding modules (ABM and TBM) inside a single, well-defined artificial molecule was certainly demonstrated to advertise the formation of an interacting ternary complicated between each the antibodies and the focused cell, which often leads to the simultaneous immune-mediated mobile destruction. In a preliminary research, we’ve got described the first Antibody Recruiting Glycodendrimers (ARGs), combining cRGD as ligands for the αVβ3-expressing melanoma cell line M21 and Rha as ligand for pure IgM, and demonstrated that multivalency is an important requirement to type this complicated.

Within the current research, we synthesized a brand new collection of ARGs composed of ABMs, i.e. self-condensed rhamnosylated cyclopeptide and polylysine dendrimer, which have been conjugated to the TBM with or with out spacer. Circulation cytometry and confocal microscopy experiments with human serum and completely different cell traces revealed that the ABM geometry considerably influences the ternary complicated formation in M21, whereas no vital binding happens in BT 549 having low integrin expression.

As well as, we exhibit with a mobile viability assay that ARGs induce excessive stage of cytotoxicity in opposition to M21 which can be in shut correlation with the ABM construction. Particularly, we’ve got proven that ARG combining cyclopeptide core and branches, with or with out spacer, induce 40-57% of selective cytotoxicity in opposition to M21 cells within the presence of human serum because the distinctive supply of immunity effectors. Lastly, we additionally spotlight that the spacer between ABM and TBM allows a rise of the immune-mediate cytotoxicity even with ABM of decrease valency.

ICELISA na bazie przeciwciał monoklonalnych do badania przesiewowego diazynonu w próbkach warzyw

 

Diazinon (DAZ) is an organophosphorus pesticide (OP), which is usually used to stop and management dangerous pests that endanger agricultural merchandise. On this research, we developed a novel heterology coating technique for the immunoassay of DAZ. The DAZ coating hapten may be instantly conjugated to the provider protein with out requiring a spacer arm. This proposed hapten coating technique is time-saving and considerably improves the sensitivity of the immunoassay as a result of lack of a spacer arm. The as-synthesized coating antigen was used to display screen the monoclonal antibody (mAb).

Lastly, the developed oblique aggressive enzyme-linked immunoassay (icELISA) confirmed IC50 and restrict of detection (LOD) values of 0.58 ng mL-1 and eight pg mL-1, respectively. This technique exhibited negligible cross-reactivity in direction of different analogues, and the recoveries of samples (cucumber, cabbage, and lettuce) ranged from 92.6% to 125.4%, with coefficients of variance (CV) under 12%. Good correlation between icELISA and high-performance liquid chromatography mass spectrometry (HPLC-MS/MS) was obtained. The proposed icELISA was an excellent software for monitoring DAZ residues in meals samples.

Human Neurotensin (NT) ELISA Kit

RDR-NT-Hu-48Tests 48 Tests
EUR 522

Human Neurotensin (NT) ELISA Kit

RDR-NT-Hu-96Tests 96 Tests
EUR 724

Human Neurotensin (NT) ELISA Kit

RD-NT-Hu-48Tests 48 Tests
EUR 500

Human Neurotensin (NT) ELISA Kit

RD-NT-Hu-96Tests 96 Tests
EUR 692

Anti-NT-3 antibody

STJ98718 200 µl
EUR 197
Description: NT-3 is a protein encoded by the NTF3 gene which is approximately 29,4 kDa. NT-3 is secreted and is involved in apoptotic pathways in synovial fibroblasts, the GPCR pathway, ERK signalling, TGF-beta pathway and nanog in mammalian ESC pluripotency. This protein falls under the neurotrophin family. It controls survival and differentiation of mammalian neurons and is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo. NT-3 is expressed in the brain and peripheral tissues. Mutations in the NTF3 gene result in diabetic neuropathy and pediatric fibrosarcoma. STJ98718 was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. This polyclonal antibody binds to endogenous NT-3.

Nitrotyrosine (NT) ELISA Kit

DLR-NT-Ge-48T 48T
EUR 575
  • Should the Nitrotyrosine (NT) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A competitive inhibition quantitative ELISA assay kit for detection of Nitrotyrosine (NT) in samples from serum, plasma, tissue homogenates or other biological fluids.

Nitrotyrosine (NT) ELISA Kit

DLR-NT-Ge-96T 96T
EUR 753
  • Should the Nitrotyrosine (NT) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A competitive inhibition quantitative ELISA assay kit for detection of Nitrotyrosine (NT) in samples from serum, plasma, tissue homogenates or other biological fluids.

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Rat Neurotensin (NT) ELISA Kit

DLR-NT-Ra-48T 48T
EUR 528
  • Should the Rat Neurotensin (NT) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A competitive inhibition quantitative ELISA assay kit for detection of Rat Neurotensin (NT) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Neurotensin (NT) ELISA Kit

DLR-NT-Ra-96T 96T
EUR 690
  • Should the Rat Neurotensin (NT) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A competitive inhibition quantitative ELISA assay kit for detection of Rat Neurotensin (NT) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

General Nitrotyrosine (NT) ELISA Kit

RDR-NT-Ge-48Tests 48 Tests
EUR 613

General Nitrotyrosine (NT) ELISA Kit

RDR-NT-Ge-96Tests 96 Tests
EUR 854

Rat Neurotensin (NT) ELISA Kit

RDR-NT-Ra-48Tests 48 Tests
EUR 558

Rat Neurotensin (NT) ELISA Kit

RDR-NT-Ra-96Tests 96 Tests
EUR 776

Rat Neurotensin (NT) ELISA Kit

RD-NT-Ra-48Tests 48 Tests
EUR 534

Rat Neurotensin (NT) ELISA Kit

RD-NT-Ra-96Tests 96 Tests
EUR 742

NT-3

GT15000 100 ug
EUR 526

NT-3

GT15128 100 ug
EUR 500

Anti-NT Antibody

A03097 100ul
EUR 397
Description: Rabbit Polyclonal NT Antibody. Validated in WB and tested in Human.

Anti-SUMO-2/3 (NT) Antibody

A01282 100ul/vial
EUR 442
Description: Rabbit Polyclonal SUMO-2/3 (NT) Antibody. Validated in WB and tested in Human.

NT-3/ Rat NT- 3 ELISA Kit

ELA-E0106r 96 Tests
EUR 886

NT-3, human recombinant

4306-10
EUR 267

NT-3, human recombinant

4306-1000
EUR 5362

NT-3, human recombinant

4306-50
EUR 729

Nitrotyrosine (NT/3-NT) CLIA Kit

20-abx490435
  • EUR 7973.00
  • EUR 4246.00
  • EUR 981.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests
  • Please enquire.

Anti-VEGF Receptor 3/FLT4 Antibody

A01276-3 100ug/vial
EUR 334

Anti-14-3-3 alpha + beta Rabbit Monoclonal Antibody

M02431-3 100ug/vial
EUR 397
Description: Rabbit Monoclonal 14-3-3 alpha + beta Antibody. Validated in Flow Cytometry, IP, IF, IHC, ICC, WB and tested in Human, Mouse, Rat.

Anti-NT-4 Antibody

A06935-2 100ul
EUR 397
Description: Rabbit Polyclonal NT-4 Antibody. Validated in IHC and tested in Human, Mouse, Rat.

Anti-BACE2 (NT) Antibody

A02963 100ug
EUR 483
Description: Rabbit Polyclonal BACE2 (NT) Antibody. Validated in IHC, WB and tested in Human, Mouse, Rat.

Anti-PHAP (NT) Antibody

A03625 100ug
EUR 471
Description: Rabbit Polyclonal PHAP (NT) Antibody. Validated in WB and tested in Human, Mouse, Rat.

Anti-CX3CR1 (NT) Antibody

A00280 100ug
EUR 471
Description: Rabbit Polyclonal CX3CR1 (NT) Antibody. Validated in IHC, WB and tested in Human, Mouse, Rat.

anti- NT-proBNP antibody

FNab10151 100µg
EUR 548.75
  • Immunogen: NT-proBNP
  • Uniprot ID: P16860
  • Gene ID: 4879
  • Research Area: Stem Cells, Cardiovascular
Description: Antibody raised against NT-proBNP

Anti-NT-proBNP antibody

STJ400145 1 mg
EUR 446
Description: The plasma concentrations of both the N-terminal fragment of Pro-B-type natriuretic peptide (NT-proBNP) and prohormone of brain natriuretic peptide (proBNP) are significantly increased in patients with asymptomatic and symptomatic left ventricular dysfunction.

Anti-NT-proBNP antibody

STJ400146 1 mg
EUR 446
Description: The plasma concentrations of both the N-terminal fragment of Pro-B-type natriuretic peptide (NT-proBNP) and prohormone of brain natriuretic peptide (proBNP) are significantly increased in patients with asymptomatic and symptomatic left ventricular dysfunction.

Anti-NT-4 antibody

STJ94562 200 µl
EUR 197
Description: Rabbit polyclonal to NT-4.

NT-3 Antibody

5306-200
EUR 316

NT-3 Antibody

5306-30T
EUR 146

rHu NT-3

AK8543-0002 2µg Ask for price

rHu NT-3

AK8543-0010 10µg Ask for price

rHu NT-3

AK8543-0100 100µg Ask for price

rHu NT-3

AK8543-1000 1mg Ask for price

Anti-Human Ki67 Antibody

M00254-3 100ul
EUR 397
Description: Rabbit Polyclonal Human Ki67 Antibody. Validated in IHC, WB and tested in Human, Mouse, Rat.

Anti-Human IBA1 Antibody

M01394-3 100ul
EUR 397
Description: Chicken Polyclonal Human IBA1 Antibody. Validated in IF, IHC, WB and tested in Human.

Anti-active Caspase-3 Rabbit Monoclonal Antibody

M00334-3 100ug/vial
EUR 397
Description: Anti-active Caspase-3 Rabbit Monoclonal Antibody tested for IF, IHC, ICC, WB in Human

Anti-Galectin 3/LGALS3 Antibody (monoclonal, 12B12)

M00621-3 100ug/vial
EUR 334

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Human 3-NT ELISA Kit

EHA0677 96Tests
EUR 521

Human NT-3 ELISA Kit

EHN0025 96Tests
EUR 521

NT-3 ELISA KIT|Human

EF000198 96 Tests
EUR 689

Human NT-3 ELISA kit

LF-EK50297 1×96T
EUR 648

Recombinant Human NT-3 Protein

PROTP20783-1 10ug
EUR 317
Description: NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant human NT-3 is a noncovalently linked homodimer, of two 13.6 kDa polypeptide monomers (240 total amino acid residues). Human and Mouse NT-3 sequences are identical.

Human N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) ELISA Kit

DLR-NT-ProANP-Hu-48T 48T
EUR 479
  • Should the Human N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) ELISA Kit

DLR-NT-ProANP-Hu-96T 96T
EUR 621
  • Should the Human N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit

DLR-NT-ProBNP-Hu-48T 48T
EUR 404
  • Should the Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit

DLR-NT-ProBNP-Hu-96T 96T
EUR 518
  • Should the Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) ELISA Kit

RDR-NT-ProANP-Hu-48Tests 48 Tests
EUR 500

Human N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) ELISA Kit

RDR-NT-ProANP-Hu-96Tests 96 Tests
EUR 692

Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit

RDR-NT-ProBNP-Hu-48Tests 48 Tests
EUR 411

Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit

RDR-NT-ProBNP-Hu-96Tests 96 Tests
EUR 565

Human N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) ELISA Kit

RD-NT-ProANP-Hu-48Tests 48 Tests
EUR 478

Human N-Terminal Pro Atrial Natriuretic Peptide (NT-ProANP) ELISA Kit

RD-NT-ProANP-Hu-96Tests 96 Tests
EUR 662

Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit

RD-NT-ProBNP-Hu-48Tests 48 Tests
EUR 393

Human N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit

RD-NT-ProBNP-Hu-96Tests 96 Tests
EUR 541

Anti-Glyceraldehyde 3-Phosphate Dehydrogenase [GAPDH] Monoclonal Antibody

M00227-3 100ul
EUR 397
Description: Mouse Monoclonal Glyceraldehyde 3-Phosphate Dehydrogenase [GAPDH] Antibody. Validated in IHC, WB and tested in Equine.

Human N-Terminal Pro C-Type Natriuretic Peptide (NT-ProCNP) ELISA Kit

DLR-NT-ProCNP-Hu-48T 48T
EUR 517
  • Should the Human N-Terminal Pro C-Type Natriuretic Peptide (NT-ProCNP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A competitive inhibition quantitative ELISA assay kit for detection of Human N-Terminal Pro C-Type Natriuretic Peptide (NT-ProCNP) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human N-Terminal Pro C-Type Natriuretic Peptide (NT-ProCNP) ELISA Kit

DLR-NT-ProCNP-Hu-96T 96T
EUR 673
  • Should the Human N-Terminal Pro C-Type Natriuretic Peptide (NT-ProCNP) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A competitive inhibition quantitative ELISA assay kit for detection of Human N-Terminal Pro C-Type Natriuretic Peptide (NT-ProCNP) in samples from serum, plasma, tissue homogenates or other biological fluids.

Human N-Terminal Pro C-Type Natriuretic Peptide (NT-ProCNP) ELISA Kit

RDR-NT-ProCNP-Hu-48Tests 48 Tests
EUR 544

Human N-Terminal Pro C-Type Natriuretic Peptide (NT-ProCNP) ELISA Kit

RDR-NT-ProCNP-Hu-96Tests 96 Tests
EUR 756

Human N-Terminal Pro C-Type Natriuretic Peptide (NT-ProCNP) ELISA Kit

RD-NT-ProCNP-Hu-48Tests 48 Tests
EUR 521

Human N-Terminal Pro C-Type Natriuretic Peptide (NT-ProCNP) ELISA Kit

RD-NT-ProCNP-Hu-96Tests 96 Tests
EUR 723

Anti-Osteopontin (NT) (Clone 2C5)

5422-100
EUR 338

Anti-Osteopontin (NT) (Clone 2F10)

5423-100
EUR 354

Anti-Osteopontin (NT) (Clone 2E11)

5424-100
EUR 338

Anti-Osteopontin (NT) (Clone 2H9)

5425-100
EUR 338

Anti-NT-Pro-BNP(Lable)

E63C00504 100ug
EUR 382

Anti-NT-proBNP 1308 antibody

STJ400230 1 mg
EUR 446

Anti-NT-proBNP 1311 antibody

STJ400234 1 mg
EUR 446

Anti-NT-proBNP 1312 antibody

STJ400235 1 mg
EUR 446

Anti-NT-proBNP 1310 antibody

STJ400236 1 mg
EUR 446

Anti-NT-proBNP 1307 antibody

STJ400237 1 mg
EUR 446

NT-3, murine recombinant

4307-10
EUR 316

NT-3, murine recombinant

4307-1000
EUR 6422

NT-3, murine recombinant

4307-50
EUR 865

NT-3 Polyclonal Antibody

46794-100ul 100ul
EUR 252

NT-3 Polyclonal Antibody

46794-50ul 50ul
EUR 187

Polyclonal NT-3 Antibody

AMM06836G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human NT-3 . This antibody is tested and proven to work in the following applications:

NT-3 Polyclonal Antibody

ABP59544-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from part region of human NT-3 protein at amino acid sequence of 180-230
  • Applications tips:
Description: A polyclonal antibody for detection of NT-3 from Human, Mouse, Rat. This NT-3 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human NT-3 protein at amino acid sequence of 180-230

NT-3 Polyclonal Antibody

ABP59544-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from part region of human NT-3 protein at amino acid sequence of 180-230
  • Applications tips:
Description: A polyclonal antibody for detection of NT-3 from Human, Mouse, Rat. This NT-3 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human NT-3 protein at amino acid sequence of 180-230

NT-3 Polyclonal Antibody

ABP59544-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from part region of human NT-3 protein at amino acid sequence of 180-230
  • Applications tips:
Description: A polyclonal antibody for detection of NT-3 from Human, Mouse, Rat. This NT-3 antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human NT-3 protein at amino acid sequence of 180-230

NT-3 Polyclonal Antibody

ES8655-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against NT-3 from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

NT-3 Polyclonal Antibody

ES8655-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against NT-3 from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

NT-3 GMP, CF

PR15120CF 5 ug
EUR 584

Rabbit Anti-Human Neurotensin (NT) antiserum # 1

NT61-S 100 ul
EUR 457

Human Neurotrophin-3,NT-3 ELISA KIT

201-12-1306 96 tests
EUR 440
  • This Neurotrophin-3 ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human 3-Nitrotyrosine,3-NT ELISA Kit

201-12-1426 96 tests
EUR 440
  • This 3-Nitrotyrosine ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Neurotrophin-3, NT-3 ELISA KIT

CSB-E04686h-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Neurotrophin-3, NT-3 in samples from serum, plasma, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

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