ciężkości COVID-19 za pomocą swoistego przeciwciała

Przewidywanie ciężkości COVID-19 za pomocą swoistego przeciwciała nukleokapsydowego i wskaźnika czynnika ryzyka choroby

 

Efficient strategies for predicting COVID-19 illness trajectories are urgently wanted. Right here, enzyme-linked immunosorbent assay (ELISA) and coronavirus antigen microarray (COVAM) evaluation mapped antibody epitopes within the plasma of COVID-19 sufferers (n = 86) experiencing a variety of illness states. The experiments recognized antibodies to a 21-residue epitope from nucleocapsid (termed Ep9) related to extreme illness, together with admission to the intensive care unit (ICU), requirement for ventilators, or dying.

Importantly, anti-Ep9 antibodies will be detected inside 6 days post-symptom onset and generally inside 1 day. Moreover, anti-Ep9 antibodies correlate with varied comorbidities and hallmarks of immune hyperactivity. We introduce a simple-to-calculate, illness danger issue rating to quantitate every affected person’s comorbidities and age. For sufferers with anti-Ep9 antibodies, scores above 3.Zero predict extra extreme illness outcomes with a 13.42 probability ratio (96.7% specificity).

The outcomes lay the groundwork for a brand new kind of COVID-19 prognostic to permit early identification and triage of high-risk sufferers. Such data may information simpler therapeutic intervention.IMPORTANCE The COVID-19 pandemic has resulted in over two million deaths worldwide. Regardless of efforts to struggle the virus, the illness continues to overwhelm hospitals with severely ailing sufferers.

Analysis of COVID-19 is quickly completed by means of a mess of dependable testing platforms; nonetheless, prognostic prediction stays elusive. To this finish, we recognized a brief epitope from the SARS-CoV-2 nucleocapsid protein and likewise a illness danger issue rating based mostly upon comorbidities and age. The presence of antibodies particularly binding to this epitope plus a rating cutoff can predict extreme COVID-19 outcomes with 96.7% specificity.

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Recombinant Human IGF BP7

HEGFP-0907 5ug Ask for price

IGF BP3 antibody

70R-IR022 50 ug
EUR 327.6
Description: Affinity purified Rabbit polyclonal IGF BP3 antibody

IGF BP5 antibody

70R-IR023 50 ug
EUR 327.6
Description: Affinity purified Rabbit polyclonal IGF BP5 antibody

IGF BP7 antibody

70R-IR024 50 ug
EUR 327.6
Description: Affinity purified Rabbit polyclonal IGF BP7 antibody

IGF-BP3, Human

HY-P7020 10ug
EUR 280.8

IGF-BP5, Human

HY-P7021 50ug
EUR 721.2

IGF-BP3, human

RC216-12B3 5ug
EUR 125.26

Rabbit Anti Human RIPK1 Monoclonal Clone IGF-18

IRBAHURIPK1IGF18C100UL each
EUR 496
Description: Rabbit Anti Human RIPK1 Monoclonal Clone IGF-18

IGF BP2 protein

30R-AI105 20 ug
EUR 327.6
Description: Purified recombinant Human IGF BP2 protein

IGF BP6 protein

30R-AI106 25 ug
EUR 327.6
Description: Purified recombinant Human IGF BP6 protein

IGF BP7 protein

30R-AI120 25 ug
EUR 327.6
Description: Purified recombinant Human IGF BP7 protein

IGF BP1 protein

30R-AI121 25 ug
EUR 327.6
Description: Purified recombinant Human IGF BP1 protein

IGF BP3 protein

30R-AI122 25 ug
EUR 327.6
Description: Purified recombinant Human IGF BP3 protein

IGF BP5 protein

30R-AI124 25 ug
EUR 327.6
Description: Purified recombinant Human IGF BP5 protein

IGF-1, Human

HY-P7018 10ug
EUR 129.6

IGF-2, Human

HY-P7019 100ug
EUR 432

IGF-1, human

RC216-12 1mg
EUR 451.5

Antibody for Human IGF-1

SPC-699D-ALP 0.1mg
EUR 472.8
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to Alkaline Phosphatase.

Antibody for Human IGF-1

SPC-699D-DY350 0.1mg
EUR 496.8
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to Dylight 350.

Antibody for Human IGF-1

SPC-699D-DY405 0.1mg
EUR 483.6
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to Dylight 405.

Antibody for Human IGF-1

SPC-699D-DY488 0.1mg
EUR 471.6
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to Dylight 488.

Antibody for Human IGF-1

SPC-699D 0.1mg
EUR 424.8
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is unconjugated.

Antibody for Human IGF-1

SPC-699D-A390 0.1mg
EUR 481.2
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to ATTO 390.

Antibody for Human IGF-1

SPC-699D-A488 0.1mg
EUR 480
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to ATTO 488.

Antibody for Human IGF-1

SPC-699D-A565 0.1mg
EUR 480
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to ATTO 565.

Antibody for Human IGF-1

SPC-699D-A594 0.1mg
EUR 480
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to ATTO 594.

Antibody for Human IGF-1

SPC-699D-A633 0.1mg
EUR 480
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to ATTO 633.

Antibody for Human IGF-1

SPC-699D-A655 0.1mg
EUR 480
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to ATTO 655.

Antibody for Human IGF-1

SPC-699D-A680 0.1mg
EUR 480
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to ATTO 680.

Antibody for Human IGF-1

SPC-699D-A700 0.1mg
EUR 480
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to ATTO 700.

Antibody for Human IGF-1

SPC-699D-APC 0.1mg
EUR 478.8
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to APC .

Antibody for Human IGF-1

SPC-699D-APCCY7 0.1mg
EUR 565.2
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to APC/Cy7.

Antibody for Human IGF-1

SPC-699D-BI 0.1mg
EUR 475.2
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to Biotin.

Antibody for Human IGF-1

SPC-699D-DY594 0.1mg
EUR 474
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to Dylight 594.

Antibody for Human IGF-1

SPC-699D-DY633 0.1mg
EUR 468
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to Dylight 633.

Antibody for Human IGF-1

SPC-699D-FITC 0.1mg
EUR 470.4
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to FITC.

Antibody for Human IGF-1

SPC-699D-HRP 0.1mg
EUR 465.6
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to HRP.

Antibody for Human IGF-1

SPC-699D-P594 0.1mg
EUR 488.4
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to PE/ATTO 594.

Antibody for Human IGF-1

SPC-699D-PCP 0.1mg
EUR 478.8
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to PerCP.

Antibody for Human IGF-1

SPC-699D-RPE 0.1mg
EUR 476.4
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to RPE .

Antibody for Human IGF-1

SPC-699D-STR 0.1mg
EUR 477.6
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is conjugated to Streptavidin.

Antibody for Human IGF-1

SPC-699S 0.012mg
EUR 78
Description: A polyclonal antibody for IGF-1 from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the mid-protein of Human IGF-1. The Antibody is tested and validated for WB, ICC/IF, IHC assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100); IHC (1:50). This IGF-1 antibody is unconjugated.

Human Salivary IGF(salivary IGF) ELISA Kit

QY-E05383 96T
EUR 433.2

IGF-I, Human

E34M113H 20 μg
EUR 155
Description: Recombinant Human Cytotoxic T-lymphocyte Protein 4 is produced by our Mammalian expression system and the target gene encoding Lys36-Asp161 is expressed with a Flag tag at the C-terminus.

IGF-II, Human

E34M114H 5 μg
EUR 155

Human IGF-1 LR3

SP-89927-100 100 ug
EUR 270

PE anti-human CD221 (IGF-1R)

E16FHP221-025 25 tests
EUR 476.67
Description: Available in various conjugation types.

PE anti-human CD221 (IGF-1R)

E16FHP221-100 100 tests
EUR 1083.33
Description: Available in various conjugation types.

Purified anti-human CD221 (IGF-1R)

E16FHU221-100U 100 μg
EUR 520
Description: Available in various conjugation types.

Recombinant Human IGF-1

HEGFP-0901 100ug Ask for price

Recombinant Human IGF-2

HEGFP-0908 10ug Ask for price

IGF-BP2, human recombinant

7165-10 each
EUR 301.2

IGF-BP2, human recombinant

7165-50 each
EUR 1123.2

IGF-BP7, human recombinant

7167-10 each
EUR 248.4

IGF-BP7, human recombinant

7167-50 each
EUR 810

IGF-BP6, human recombinant

7350-20 each
EUR 444

IGF-BP1, human recombinant

4717-100 each
EUR 744

IGF-BP1, human recombinant

4717-1000 each
EUR 3778.8

IGF-BP1, human recombinant

4717-25 each
EUR 307.2

IGF-BP3, human recombinant

4720-100 each
EUR 744

IGF-BP3, human recombinant

4720-1000 each
EUR 3778.8

IGF-BP3, human recombinant

4720-25 each
EUR 307.2

IGF-BP5, human recombinant

4723-100 each
EUR 744

IGF-BP5, human recombinant

4723-1000 each
EUR 3778.8

IGF-BP5, human recombinant

4723-25 each
EUR 307.2

IGF-1, human recombinant

P1016-.02 20 µg
EUR 309.6
Description: Insulin-like growth factor I (IGF-1) is a polypeptide endocrine hormone structurally similar to insulin and is mainly produced in the liver when stimulated by growth hormone. IGF-1 is a growth factor that stimulates the proliferation of various cell types including muscle, bone, and cartilage tissue

IGF-1, human recombinant

P1016-.1 100 µg
EUR 915.6
Description: Insulin-like growth factor I (IGF-1) is a polypeptide endocrine hormone structurally similar to insulin and is mainly produced in the liver when stimulated by growth hormone. IGF-1 is a growth factor that stimulates the proliferation of various cell types including muscle, bone, and cartilage tissue

Human IGF-I monoclonal antibody

MAM1 500 µg
EUR 358.8

Anti-Rat IGF-1 Antibody

5121-100 each
EUR 379.2

Anti-Rat IGF-1 Antibody

5121-30T each
EUR 175.2

rec IGF-I (human)

H-5555.0050 50.0µg
EUR 290.4
Description: CAS# [67763-96-6]

rec IGF-I (human)

H-5555.0100 100.0µg
EUR 457.2
Description: CAS# [67763-96-6]

rec IGF-I (human)

H-5555.0500 0.5mg
EUR 1720.8
Description: CAS# [67763-96-6]

Human IGF-BP1 ELISA kit

E22-HC145.48 48T
EUR 295

Human IGF-BP1 ELISA kit

E22-HC145.96 96T
EUR 395

Human IGF-I Protein

abx060791-100ug 100 ug
EUR 560.4

Biotinyl Human IGF-I

AQU010 10 µg
EUR 303.6

Biotinyl Human IGF-I

AQU050 50 µg
EUR 415.2

Biotinyl Human IGF-I

AQU100 100 µg
EUR 637.2

Biotinyl Human IGF-I

AQU500 500 µg
EUR 1305.6

Human [Ala31] IGF-I

AIU020 20 µg
EUR 303.6

Human [Ala31] IGF-I

AIU100 100 µg
EUR 415.2

Human [Leu60] IGF-I

ABU020 20 µg
EUR 303.6

Human [Leu60] IGF-I

ABU100 100 µg
EUR 415.2

Human [Arg6] IGF-II

GU020 20 µg
EUR 303.6

Human [Leu24] IGF-I

ZU020 20 µg
EUR 303.6

Human [Leu24] IGF-I

ZU100 100 µg
EUR 415.2

Recombinant Human IGF-2/ IGF-II Protein, GST, E.coli-1mg

QP8601-ec-1mg 1mg
EUR 1958.4

Recombinant Human IGF-2/ IGF-II Protein, GST, E.coli-10ug

QP8601-ec-10ug 10ug
EUR 240

Recombinant Human IGF-2/ IGF-II Protein, GST, E.coli-50ug

QP8601-ec-50ug 50ug
EUR 315.6

Human [Leu27]IGF-II

TU100 100 µg
EUR 415.2

Recombinant Human IGF-2/ IGF-II Protein, GST, E.coli-100ug

QP8601-ec-100ug 100ug
EUR 489.6

Recombinant Human IGF-2/ IGF-II Protein, GST, E.coli-200ug

QP8601-ec-200ug 200ug
EUR 760.8

Recombinant Human IGF-2/ IGF-II Protein, GST, E.coli-500ug

QP8601-ec-500ug 500ug
EUR 1272

Human IGF-2 ELISA Kit

EHI0307 96Tests
EUR 625.2

Human IGF-1 ELISA Kit

RK00160 96 Tests
EUR 625.2

Human IGF-1 ELISA Kit

E28L0569 96T
EUR 666.67

Human IGF-1 ELISA KIT

E42EH-82 96T/48T Ask for price

Recombinant Human IGF-2/ IGF-II Protein, Untagged, E.coli-1mg

QP5264-1mg 1mg
EUR 1513.2

Recombinant Human IGF-2/ IGF-II Protein, Untagged, E.coli-10ug

QP5264-10ug 10ug
EUR 163.2

Recombinant Human IGF-2/ IGF-II Protein, Untagged, E.coli-50ug

QP5264-50ug 50ug
EUR 284.4

Recombinant Human IGF-2/ IGF-II Protein, Untagged, E.coli-100ug

QP5264-100ug 100ug
EUR 435.6

Recombinant Human IGF-2/ IGF-II Protein, Untagged, E.coli-500ug

QP5264-500ug 500ug
EUR 914.4

Recombinant Human IGF-BP1 Protein

PROTP08833-1 25ug
EUR 380.4
Description: IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP1 is a 25.4 kDa cysteine-rich secreted protein expressed in liver, deciduas, and kidneys and is the most abundant IGF-BP in amniotic fluid. Levels of IGF-BP1 in serum are lowest after food. IGF-BP1 binds to both IGF-I and IGF-II with equal affinity. Phosphorylated IGF-BP1 hinders IGF actions, where as nonphosphorylated IGF-BP1 is stimulatory. Recombinant human IGF-BP1 is a 25.4 kDa protein consisting of 235 amino acid residues (Isoform A).

Recombinant Human IGF-BP3 Protein

PROTP17936-2 25ug
EUR 380.4
Description: IGF-BP3 is a 30 kDa cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals and it is also found in α-granules of platelets. In addition to its ability to modulate the activity of IGF-I and IGF-II, IGF-BP3 exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF. Recombinant human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues.

Recombinant Human IGF-BP2 Protein

PROTP18065 20ug
EUR 380.4
Description: IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP2 is a cysteine-rich secreted protein produced by bone cells, and is most abundant in the brain. IGF-BP2 has been shown to inhibit IGF-II action in human breast and ovarian carcinoma cells. Recombinant human IGF-BP2 is a 31.5 kDa protein consisting of 289 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.

*Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.

Recombinant Human IGF-BP6 Protein

PROTP24592-2 20ug
EUR 380.4
Description: IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP6 is produced by bone cells and is the major IGF-BP present in cerebrospinal fluid, and specifically inhibits IGF-II actions. IGF-BP6 has been shown to inhibit IGF-II-dependent cancers such as neuroblastoma, colon cancer and rhabdomyosarcoma. Recombinant human IGF-BP6 has a calculated mass of 22.6 kDa and consists of 213 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain. IGF-BP6 migrates at an apparent molecular weight of approximately 23.0-30.0 kDa by SDS-PAGE analysis under non-reducing conditions.

*Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.

Recombinant Human IGF-BP5 Protein

PROTP24593-1 25ug
EUR 380.4
Description: IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP5 is a 28.6 kDa cysteine-rich secreted protein produced by vascular smooth muscle cells. It is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGF-I on smooth muscle cells, fibroblasts or osteoblasts. Data shows that IGFBP-5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGFBP-5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole-body growth inhibition and retarded muscle development. Recombinant human IGF-BP5 is a 28.6 kDa protein consisting of 253 amino acid residues.

Recombinant Human IGF-BP7 Protein

PROTQ16270-2 25ug
EUR 380.4
Description: IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP7 is expressed in a wide range of normal human tissues and it generally shows reduced expression in cancer cell lines of prostate, breast, colon, and lung origin. It plays a role in skeletal myogenesis by binding to IGF in a manner that inhibits IGF induced differentiation of skeletal myoblasts, without affecting IGF induced proliferation. Additionally, IGF-BP7 suppresses growth and colony formation of prostate and breast cancer cell lines through an IGF independent mechanism, which causes a delay in the G1 phase of the cell cycle, and increased apoptosis. Recombinant human IGF-BP7 is a 26.4 kDa protein consisting of 256 amino acid residues.

NE Purified anti-human CD221 (IGF-1R)

E16FHY221-500U 500 μg
EUR 1625
Description: Available in various conjugation types.

Związek między poziomami alarmin w surowicy a wskaźnikami specyficznymi dla choroby u pacjentów z zapaleniem naczyń związanym z cytoplazmatycznymi przeciwciałami przeciw neutrofilom

 

Background/goal: We evaluated the connection between serum alarmin ranges and disease-specific indices in sufferers with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).

Sufferers and strategies: Sera and knowledge from 79 sufferers have been utilized. For AAV-specific indices, Birmingham vasculitis exercise rating (BVAS), five-factor rating (FFS), and vasculitis harm index (VDI) have been collected and serum ranges of 4 alarmins (hepatoma-derived progress issue, excessive mobility group field protein 1, S100A9, and S100A12) have been measured utilizing enzyme-linked immunosorbent assay. Associations between alarmin ranges, AAV-specific indices, and inflammatory laboratory markers have been assessed.

Outcomes: S100A9 ranges have been considerably correlated with C-reactive protein ranges (r=0.316, p=0.005) and S100A12 ranges correlated with VDI (r=0.232, p=0.040), which was constant in a subgroup of sufferers with myeloperoxidase (perinuclear)-ANCA positivity. No different associations have been discovered between alarmin ranges and BVAS, FFS, and VDI.

Conclusion: The serum S100A12 degree was related to organ harm in AAV, particularly in myeloperoxidase (perinuclear)-ANCA-positive sufferers.

Zapalenie skórno-mięśniowe z dodatnim przeciwciałem anty-MDA5 z szybko postępującą śródmiąższową chorobą płuc: opis dwóch przypadków

 

Melanoma differentiation-associated protein 5 (MDA5) antibody-positive dermatomyositis (DM) shows distinctive cutaneous and pathologic options. We describe two circumstances of myositis-associated quickly progressive interstitial lung illness (RP-ILD).

The sufferers have been two ladies from Kerala, India. Each sufferers had anti-MDA5 antibody-positive myositis. Each sufferers introduced with RP-ILD with none medical options of myositis and succumbed to their sickness regardless of aggressive medical remedy. Anti-MDA5-antibody-positive DM is characterised by amyopathic illness with quickly progressive and deadly ILD.

Charakterystyka przeciwciał monoklonalnych przeciw tężcowi jako pierwszy krok w kierunku opracowania testu immunologicznego na siłę szczepionki in vitro

 

Batch launch testing for human and veterinary tetanus vaccines nonetheless depends closely on strategies that contain animals, significantly for efficiency testing. The amount and high quality of tetanus antigen current in these merchandise is of utmost significance for product security and medical impact. Immunochemical strategies that measure consistency of antigen content material and high quality, doubtlessly as an indicator of efficiency, might be a better option and negate the necessity for an in vivo efficiency take a look at. These immunochemical strategies require not less than one nicely characterised monoclonal antibody (mAb) that’s particular for the goal antigen. On this paper we report the outcomes of the great characterisation of a panel of mAbs towards tetanus with a view to pick antibodies that can be utilized for growth of an in vitro efficiency immunoassay.

We’ve got assessed binding of the antibodies to native antigen (toxin), detoxified antigen (toxoid), adsorbed antigen and heat-altered antigen. Antibody perform was decided utilizing an in-house cell-based neutralisation assay to help prior in vivo efficiency knowledge that was accessible for some, however not all, of the antibodies. As well as, antibody affinity was measured, and epitope competitors evaluation was carried out to determine pairs of antibodies that might be deployed in a sandwich immunoassay format. Not all characterisation checks supplied proof of “superiority” of 1 mAb over one other, however collectively the outcomes from all characterisation research allowed for choice of an antibody pair to be taken ahead to assay growth.

Opis przypadku: autoimmunologiczne zapalenie mózgu związane z przeciwciałami dekarboksylazy kwasu przeciwglutaminowego: seria przypadków pediatrycznych

Background: Antibodies towards glutamic acid decarboxylase (GAD) are related to varied neurologic situations described in sufferers, together with stiff particular person syndrome, cerebellar ataxia, refractory epilepsy, and limbic and extralimbic encephalitis. There have been some case experiences and investigations concerning anti-GAD65 antibody-associated encephalitis in grownup populations, however pediatric circumstances are uncommon. We retrospectively analyzed the medical knowledge of three anti-GAD65 antibody-positive sufferers to discover the range and medical options of anti-GAD65 antibody-associated pediatric autoimmune encephalitis.

Strategies: The medical knowledge of a sequence of three sufferers optimistic for anti-GAD65 antibody have been retrospectively analyzed. GAD65 antibodies have been decided in serum and CSF utilizing a cell-based assay.

Outcomes: All three sufferers have been feminine, and the onset ages have been four years and 9 months, 6 years, and 16 years outdated. Their medical phenotypes included autoimmune limbic encephalitis, extralimbic encephalitis, and encephalitis combining limbic and extralimbic encephalitis. The medical signs included seizures, reminiscence deficits, drowsiness, dysautonomia, and headache. All sufferers had irregular carinal MRI and EEG. All sufferers acquired immunotherapy and had transiently good responsiveness, however one affected person then skilled relapse. In follow-up, one affected person with extralimbic encephalitis recovered utterly, whereas two sufferers with limbic involvement had poor outcomes with refractory focal epilepsy.

Conclusion: Along with limbic encephalitis, extralimbic encephalitis can also be an necessary phenotype in sufferers who’re optimistic for anti-GAD65 antibodies. Early analysis and immunotherapy can enhance the signs. Nonetheless, sufferers with limbic encephalitis typically have refractory epilepsy within the power part and have a poor long-term end result.

Human CXCL7 Antibody

32852-05111 150 ug
EUR 313.2

Mouse Pro-Platelet Basic Protein (CXCL7) ELISA Kit

IMSPPBPKT each
EUR 702
Description: Mouse Pro-Platelet Basic Protein (CXCL7) ELISA Kit

NAP-2 Antibody / CXCL7

R31872 100 ug
EUR 356.15
Description: Chemokine (C-X-C motif) ligand 7 (CXCL7), also known as NAP-2 or Pro-Platelet basic protein (PPBP), is a human gene. The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. Furthermore, the protein is an antimicrobial protein with bactericidal and antifungal activity.

CXCL7/NAP-2

PR27118 2 ug
EUR 229.2

Human NAP2(CXCL7)

90222-A 2 µg
EUR 130
Description: Recombinant NAP-2 is a disulfide-linked monomeric protein consisting of 71 amino acid residues and migrates as an approximately 8 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human NAP-2 (CXCL7) mature chain was expressed in E. coli.

Human NAP2(CXCL7)

90222-B 10 µg
EUR 205
Description: Recombinant NAP-2 is a disulfide-linked monomeric protein consisting of 71 amino acid residues and migrates as an approximately 8 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human NAP-2 (CXCL7) mature chain was expressed in E. coli.

CXCL7 Recombinant Protein

91-045 0.05 mg
EUR 821.4
Description: Human Chemokine (C-X-C motif) Ligand 7 (CXCL7), also known as neutrophil activating peptide 2 (NAP-2), is a member of the CXC chemokines containing an ELR domain (Glu-Leu-Arg tripeptide motif). Similar to other ELR domain containing CXC chemokines, such as IL-8 and the GRO proteins, CXCL7 binds CXCR2, chemoattracts and activates neutrophils. CXCL7, Connective Tissue Activating Protein III (CTAPIII) and beta thrombogulin ( beta TG), are proteolytically processed carboxylterminal fragments of platelet basic protein (PBP) which is found in the alphagranules of human platelets. Although CTAPIII, beta TG, and PBP represent amino-terminal extended variants of NAP2 and possess the same CXC chemokine domains, these proteins do not exhibit CXCL7/NAP2 activity. CXCL7 induces cell migration through the G-protein-linked receptor CXCR-2.

CXCL7 Recombinant Protein

92-388 0.05 mg
EUR 437.1
Description: Human Chemokine (C-X-C motif) Ligand 7 (CXCL7), also known as neutrophil activating peptide 2 (NAP-2), is a member of the CXC chemokines containing an ELR domain (Glu-Leu-Arg tripeptide motif). Similar to other ELR domain containing CXC chemokines, such as IL-8 and the GRO proteins, CXCL7 binds CXCR2, chemoattracts and activates neutrophils. CXCL7, Connective Tissue Activating Protein III (CTAPIII) and beta thrombogulin ( beta TG), are proteolytically processed carboxylterminal fragments of platelet basic protein (PBP) which is found in the alphagranules of human platelets. Although CTAPIII, beta TG, and PBP represent amino-terminal extended variants of NAP2 and possess the same CXC chemokine domains, these proteins do not exhibit CXCL7/NAP2 activity. CXCL7 induces cell migration through the G-protein-linked receptor CXCR-2.

NAP-2 Antibody / CXCL7 / PPBP

RQ4113 100 ug
EUR 356.15
Description: Chemokine (C-X-C motif) ligand 7 (CXCL7), also known as NAP2 or Pro-Platelet basic protein (PPBP), is a human gene. The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. Furthermore, the protein is an antimicrobial protein with bactericidal and antifungal activity.

NAP-2/CXCL7, Rat

HY-P7269 50ug
EUR 639.6

NAP-2, CXCL7, rat

RC352-18 2ug
EUR 125.26

ELISA kit for Mouse ?TG/PBP/CXCL7/NAP2 (Thromboglobulin, Beta)

E-EL-M1269 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Mouse ?TG/PBP/CXCL7/NAP2 (Thromboglobulin, Beta) in samples from Serum, Plasma, Cell supernatant

Mouse Chemokine (C-X-C motif) ligand 7 ( CXCL7) ELISA Kit

EKN43824-48T 48T
EUR 350.42

Mouse Chemokine (C-X-C motif) ligand 7 ( CXCL7) ELISA Kit

EKN43824-5x96T 5x96T
EUR 2377.85

Mouse Chemokine (C-X-C motif) ligand 7 ( CXCL7) ELISA Kit

EKN43824-96T 96T
EUR 500.6

Mouse Chemokine (C-X-C motif) ligand 7 ( CXCL7) ELISA Kit

EKU02713-48T 48T
EUR 514.08

Mouse Chemokine (C-X-C motif) ligand 7 ( CXCL7) ELISA Kit

EKU02713-5x96T 5x96T
EUR 3488.4

Mouse Chemokine (C-X-C motif) ligand 7 ( CXCL7) ELISA Kit

EKU02713-96T 96T
EUR 734.4

NAP-2/CXCL7, Human

HY-P7268 50ug
EUR 639.6

NAP-2, CXCL7, human

RC312-18 2ug
EUR 125.26

CXCL7/PBP Rabbit pAb

E2382615 100ul
EUR 225
Description: Available in various conjugation types.

Human CXCL7 ELISA Kit

LF-EK50893 1×96T
EUR 777.6

CXCL7 ELISA KIT|Human

EF001450 96 Tests
EUR 826.8

Human CXCL7 Antibody (Biotin Conjugate)

32852-05121 150 ug
EUR 442.8

ELISA kit for Human CXCL7

EK5304 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Human CXCL7 in samples from serum, plasma, tissue homogenates and other biological fluids.

Human CXCL7 Protein, Fc Tag

CX7-H5253 100ug
EUR 2493.1
Description: Human CXCL7 Protein, Fc Tag (CX7-H5253) is expressed from human 293 cells (HEK293). It contains AA Ala 59 - Asp 128 (Accession # P02775).

Recombinant Rat NAP-2/CXCL7

RECXP-0701 10ug Ask for price

Human CXCL7 AssayMax ELISA Kit

EC2270-1 96 Well Plate
EUR 572.4

Human CXCL7 PicoKine ELISA Kit

EK0729 96 wells
EUR 510
Description: For quantitative detection of human CXCL7 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Human CXCL7 AssayLite Antibody (RPE Conjugate)

32852-05151 150 ug
EUR 513.6

Human CXCL7 AssayLite Antibody (APC Conjugate)

32852-05161 150 ug
EUR 513.6

Recombinant Human NAP-2 (CXCL7)

HECXP-0701 10ug Ask for price

Human CXCL7 AssayLite Antibody (FITC Conjugate)

32852-05141 150 ug
EUR 513.6

Human CXCL7 AssayLite Antibody (PerCP Conjugate)

32852-05171 150 ug
EUR 565.2

Neutrophil Activating Protein-2 (CXCL7) Antibody

20-abx137035
  • EUR 427.20
  • EUR 627.60
  • 0.5 mg
  • 1 mg

Recombinant Human CXCL7/PPBP Protein

RP01599 50μg
EUR 42.25

Human CXCL7/NAP-2 ELISA Kit

E16HE0212 96T
EUR 833.33

Nori® Canine CXCL7 ELISA Kit

GR115398 96-well
EUR 461

Nori Equine CXCL7/NAP2 ELISA Kit

GR106909 96-well
EUR 461

Rat PPBP/CXCL7 PicoKine ELISA Kit

EK0731 96 wells
EUR 510
Description: For Quantitative Detection of rat CXCL7 in cell culture supernates, serum and plasma (heparin, EDTA).

NAP-2/CXCL7 (CHO-expressed), Human

HY-P7267 50ug
EUR 596.4

Human Chemokine Ligand CXCL7 ELISA Kit

IHUCXCL7KT each
EUR 890
Description: Human Chemokine Ligand CXCL7 ELISA Kit

Recombinant Human CXCL7/NAP-2 Protein

RP00829 10 μg
EUR 265.2

Recombinant Human CXCL7/NAP-2 Protein

E40KMP1735 20ug
EUR 495

ThymusChemokine‑1/CXCL7 (CHO-expressed), Rat

HY-P7301 10ug
EUR 349.2

Nori® Human CXCL7-NAP2 ELISA Kit

GR106282 96-well
EUR 461

Neutrophil Activating Protein-2 (CXCL7) Protein

20-abx261559
  • EUR 393.60
  • EUR 4101.60
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Neutrophil Activating Protein-2 (CXCL7) Protein

20-abx261561
  • EUR 393.60
  • EUR 4101.60
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Rabbit Anti Mouse Cxcl1 Polyclonal Antibody

CPBT-65100RM 0.1 mg
EUR 1057.2

Human CXCL7(Platelet basic protein) ELISA Kit

EH0007 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375pg/ml

Recombinant Human CXCL7/PPBP Protein, His Tag

E40KMH959 20ug
EUR 495
Description: Recombinant Human Cytotoxic T-lymphocyte Protein 4 is produced by our Mammalian expression system and the target gene encoding Lys36-Asp161 is expressed with a Flag tag at the C-terminus.

Human CXCL7(Platelet basic protein) ELISA Kit

EKF58055-48T 48T
EUR 396.9

Human CXCL7(Platelet basic protein) ELISA Kit

EKF58055-5x96T 5x96T
EUR 2693.25

Human CXCL7(Platelet basic protein) ELISA Kit

EKF58055-96T 96T
EUR 567

Human CXCL7 EZ-Set™ ELISA Kit (DIY Antibody Pairs)

EZ0729 5 plates/kit
EUR 321.6
Description: For the development of sandwich ELISA kit to measure human CXCL7 in cell culture supernates, cell lysates, tissue homogenates, serum and plasma (heparin, EDTA).

Human CXCL7 Recombinant Protein Tag Free Lyophilized

IHUCXCL7RTFLY50UG each
EUR 988
Description: Human CXCL7 Recombinant Protein Tag Free Lyophilized

Chemokine (C-X-C motif) ligand 7 ( CXCL7) Monoclonal Antibody

CAU29619-100ul 100ul
EUR 225.6

Chemokine (C-X-C motif) ligand 7 ( CXCL7) Monoclonal Antibody

CAU29619-200ul 200ul
EUR 282.2

Chemokine (C-X-C motif) ligand 7 ( CXCL7) Monoclonal Antibody

CAU29620-100ul 100ul
EUR 225.6

Chemokine (C-X-C motif) ligand 7 ( CXCL7) Monoclonal Antibody

CAU29620-200ul 200ul
EUR 282.2

Chemokine (C-X-C motif) ligand 7 ( CXCL7) Monoclonal Antibody

CAU29234-100ul 100ul
EUR 225.6

Chemokine (C-X-C motif) ligand 7 ( CXCL7) Monoclonal Antibody

CAU29234-200ul 200ul
EUR 282.2

Chemokine (C-X-C motif) ligand 7 ( CXCL7) Monoclonal Antibody

CAU29235-100ul 100ul
EUR 194.9

Chemokine (C-X-C motif) ligand 7 ( CXCL7) Monoclonal Antibody

CAU29235-200ul 200ul
EUR 243.6

Chemokine (C-X-C motif) ligand 7 ( CXCL7) Polyclonal Antibody

CAU28039-100ul 100ul
EUR 179

Chemokine (C-X-C motif) ligand 7 ( CXCL7) Polyclonal Antibody

CAU28039-200ul 200ul
EUR 219

Chemokine (C-X-C motif) ligand 7 ( CXCL7) Polyclonal Antibody

CAU28040-100ul 100ul
EUR 179

Chemokine (C-X-C motif) ligand 7 ( CXCL7) Polyclonal Antibody

CAU28040-200ul 200ul
EUR 219

Chemokine (C-X-C motif) ligand 7 ( CXCL7) Polyclonal Antibody

CAU28041-100ul 100ul
EUR 254.4

Chemokine (C-X-C motif) ligand 7 ( CXCL7) Polyclonal Antibody

CAU28041-200ul 200ul
EUR 317.5

Chemokine (C-X-C motif) ligand 7 ( CXCL7) Polyclonal Antibody

CAU28042-100ul 100ul
EUR 217.9

Chemokine (C-X-C motif) ligand 7 ( CXCL7) Polyclonal Antibody

CAU28042-200ul 200ul
EUR 272.2

Chemokine (C-X-C motif) ligand 7 ( CXCL7) Polyclonal Antibody

CAU28043-100ul 100ul
EUR 212.2

Chemokine (C-X-C motif) ligand 7 ( CXCL7) Polyclonal Antibody

CAU28043-200ul 200ul
EUR 265.4

Recombinant Human CXCL7/NAP-2 Protein, No Tag

E40KMH958 20ug
EUR 495
Description: LFA, EIA,CLIA,WB

Recombinant Rat Neutrophil Activating Protein-2 (CXCL7)

7-02065 2µg Ask for price

Recombinant Rat Neutrophil Activating Protein-2 (CXCL7)

7-02066 10µg Ask for price

Recombinant Rat Neutrophil Activating Protein-2 (CXCL7)

7-02067 1mg Ask for price

Rat Platelet Basic Protein / CXCL7 (PPBP) ELISA Kit

abx255841-96tests 96 tests
EUR 801.6

Pig Platelet Basic Protein / CXCL7 (PPBP) ELISA Kit

abx511493-96tests 96 tests
EUR 1093.2

Recombinant Human Neutrophil Activating Protein-2 (CXCL7)

7-02059 2µg Ask for price

Recombinant Human Neutrophil Activating Protein-2 (CXCL7)

7-02060 10µg Ask for price

Recombinant Human Neutrophil Activating Protein-2 (CXCL7)

7-02061 1mg Ask for price

Human Neutrophil Activating Protein-2 (CXCL7) , (Recombinant)

22060606-1 2 µg
EUR 146.42

Rat Pro-Platelet Basic Protein (CXCL7) ELISA Kit

IRTPPBPKT each
EUR 702
Description: Rat Pro-Platelet Basic Protein (CXCL7) ELISA Kit

Human Platelet Basic Protein / CXCL7 (PPBP) ELISA Kit

abx252283-96tests 96 tests
EUR 801.6

Mouse Anti-Human CXCL13 monoclonal antibody, clone JID662

CABT-L2832-100uL500uL 100 uL, 500 uL
EUR 602.4

Active Chemokine (C-X-C motif) ligand 7 ( CXCL7)

RPU58887-100ug 100ug
EUR 709.8

Active Chemokine (C-X-C motif) ligand 7 ( CXCL7)

RPU58887-1mg 1mg
EUR 3294.7

Active Chemokine (C-X-C motif) ligand 7 ( CXCL7)

RPU58887-50ug 50ug
EUR 522.7

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